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OptiMSM® — gold standard for exceptional MSM solutions

For 30 years, OptiMSM has established itself as the global standard for the purest, safest, and most consistent MSM available.
OptiMSM® is manufactured by Balchem® in the USA.
What is OptiMSM®

OptiMSM is a trademarked, highly valued form of methylsulfonylmethane known for its consistent purity, quality, and physical characteristics. Achieving these standards through precise manufacturing, OptiMSM meets stringent product specifications.

Composed of 34% elemental sulfur, 26% carbon, 6% hydrogen, and 34% oxygen, MSM occurs naturally in trace amounts in vegetation and animals. Created commercially through a chemical reaction mirroring the earth’s sulfur cycle, OptiMSM yields an identical molecule to that found in nature, with DMSO and hydrogen peroxide as raw ingredients and water as the byproduct.

OptiMSM® — The World’s Purest MSM
OptiMSM undergoes proprietary multi-stage distillation, removing impurities and isolating MSM molecules by utilizing unique boiling points. This process ensures extremely high purity consistently and produces a low-moisture product, reducing the risk of microbial contamination and product degradation.
Methylsulfonylmethane (MSM)

MSM — is a source of organic sulfur for optimal health. It plays a key role in forming connective tissue, including joints and skin, and is a component of our body’s antioxidant defense against oxidative stress and free radicals.

*These statements have not been evaluated by the Federal Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Harness the power of pure OptiMSM®
to provide your clients the gift of well-being

Reach out to us for exclusive partner details

OptiMSM® has earned the reputation as a quality brand that’s
trusted for its high standard of excellence


Proprietary multi-stage distillation processes guarantee a 99.9% pure product, ensuring unmatched purity and consistent, high-quality form of MSM.


30+ years of manufacturing expertise backed by ISO 9001:2015 registration, FSSC-22000 certification, HACCP, and cGMP compliance.


The only GRAS FDA-Notified, Kosher and Halal certified, gluten free, allergen-free, non-shellfish derived, vegan form of MSM and non-GMO project verified.

Published studies available upon request

OptiMSM has a well-documented record of safety, and has been studied in a wide variety of investigations.

OptiMSM® provides multiple health benefits

*These statements have not been evaluated by the Federal Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

works well in application

Addition of SiO2 helps prevent clumping, flowability, and compressibility.

adds efficacy to formulations

Recommended flavors are citrus, chocolate, and vanilla to mask bitter notes.

is extremely safe

No confirmed drug interactions.
No adverse events after 26 weeks.

efficacy is highly researched

Claims are attainable across multiple health benefit platforms.

OptiMSM® works in multiple dietary supplement applications

From tablets and two-piece capsules to powders, bars, gummies, and softgels, OptiMSM seamlessly integrates into diverse supplement applications.

Our commitment to innovation drives ongoing collaborations with experts to develop novel formats, ensuring we stay ahead of evolving consumer preferences and needs.

As a result, OptiMSM remains a versatile and reliable choice for enhancing a wide range of dietary supplements.

Frequently asked questions

Contact us for any additional questions, we’re happy to help.

OptiMSM is the purest and only GRAS FDA-Notified MSM (methylsulfonylmethane). Balchem uses a proprietary multi-stage distillation process, and every batch is third-party tested, ensuring optimal purity, quality, and consistency. In contrast to OptiMSM, other commercially available MSM uses crystallization to isolate the MSM molecule. As this crystallized material cools, occlusions can develop that trap contaminants within the MSM and lead to material that may contain heavy metals, residual water, and other impurities.

OptiMSM is made exclusively in the USA and manufactured in a single purpose cGMP-certified, ISO-registered facility to help provide essential traceability.

Kosher and Halal certified, Non-GMO project verified, gluten-free, allergen-free, non-shellfish-derived, and vegan, our OptiMSM backed by extensive toxicology data.

MSM is a naturally occurring substance found in the human body and many foods. The highest concentration of MSM in nature is in mammal milk, but these sources contain MSM in parts per million. Therefore, you cannot extract, isolate or grow the compound.

Commercially available MSM does not come from wood, plants or fossil fuels. You can’t squeeze MSM from a tree, extract it from plants or remove it from petroleum or other fossil fuels. A chemical reaction is required to make MSM.

All commercially available MSM is synthetic and created through a chemical reaction of DMSO and hydrogen peroxide. Since all commercial MSM produced comes from DMSO, and all commercial DMSO is produced synthetically, the origin of the DMSO is insignificant.

DMSO is produced using several starting materials: methanol and hydrogen sulfide, or methanol and carbon disulfide. Whichever starting materials used, chemical reactions are required to produce DMSO.

There is a misconception that one supply of MSM is more natural than another. All MSM produced for commercial use utilizes the same raw materials—but there is a difference, and that boils down to the purification process, testing levels, specifications and quality of the manufacturing.

Balchem’s focus on purity sets OptiMSM® apart. Belchem pioneered the distillation process of MSM ensuring the highest levels of purity and safety. Chemical engineers and other experts recognize the multi-stage distillation process used to purify OptiMSM as the superior method on the market. The end product is biomimetic, which means the same as that found in nature.

Every batch of OptiMSM is third-party tested, ensuring optimal purity, quality, and consistency. In contrast to OptiMSM, other commercially available MSM uses crystallization to isolate the MSM molecule.

Commercial MSM is produced from a chemical reaction between dimethyl sulfoxide (DMSO) and hydrogen peroxide (H2O2). In the reaction, the hydrogen peroxide provides an available atom of oxygen to the DMSO, forming MSM, which is also called DMSO2, and water (DMSO + H2O2 = DMSO2 + H2O).

After the reaction is complete, the MSM must be separated from the water and other reaction by-products. Separation is commonly done utilizing one of two differing processes; either crystallization or distillation. Chemical engineers recognize distillation as the superior separation method for MSM purification and if properly performed will consistently yield a product of 99.9% purity.1

Crystallization separates the MSM from the water (parent solvent) by decreasing the solubility of the MSM by cooling the solution. During crystal formation occlusions, small pockets or imperfections, form within the crystal that can entrap impurities present within the reaction mixture.2,3,4 These impurities can come from additional water added during the reaction phase, side reactions, the reactants themselves, or the catalyst which usually contains a strong mineral acid. It is pertinent to remember that one of the primary reactants is DMSO (dimethylsulfoxide). DMSO is a very strong industrial solvent, one of the few that can dissolve most epoxies. A technical bulletin from a major DMSO manufacturer states “DMSO, one of the strongest organic solvents, has been used commercially for over forty years. It is an effective solvent for a wide array of organic materials, including many polymers. DMSO also dissolves many inorganic salts, particularly transition metal nitrates, cyanides, and dichromates.”5

Distillation uses boiling point differentials to separate the MSM from the water and other impurities. Distillation is usually performed using either multiple distillation columns or multiple distillation steps within a single column. Ultimately the purified MSM is vaporized and distilled overhead resulting in an extremely pure final product. Distillation is energy intensive and a more expensive separation technique, but it ensures a product that is virtually contamination-free regardless of the level of impurities in the reaction mixture.1 U.S. based Balchem producers of OptiMSM are the only MSM producers using distillation for purification.

These two separation processes will both yield MSM that is equally bio-available.  The highest level of purity is essential to ensure the end user can achieve desired therapeutic results without having to worry about potential health issues from trace impurities.


  1. Jacob SW, Appleton J. MSM: The Definitive Guide. California: Freedom Press, 2003 188-189
  2. King CJ. Separation Processes, 2 nd ed. New York: McGraw-Hil Book Company, 1980, 732-3
  3. Bennett RC, Corder WC, Finn RK, et al. Miscellaneous separation processes. In: Perry RH, Chilton CH, eds.
    Chemical Engineer’s Handbook, 5 th ed. New York: Mcgraw- Hill Book Company1973, 17-1 to 17-58
  4. Van Hook A. Crystallization: Theory and Practice. New York: Reinhold Publishing Corporation, 1963 192-237.
  5. [No authors listed] DMSO: Dimethyl Sulfoxide (DMSO) Solubility Data technical bulletin #102B. Gaylord Chemical Corporation, Slidell, Louisiana

Informed-Ingredient is a global quality assurance program for sports nutrition products, suppliers to the sports nutrition industry, and supplement manufacturing facilities. The program certifies that every batch of a supplement product and/or raw material that bears the Informed-Ingredient logo has been tested for banned substances by LGC’s world-class sports anti-doping laboratory.

The Informed-Ingredient designation is another testament to Balchem’s continued commitment to the quality, consistency, and safety of OptiMSM.

Dependent on the liquid and the amount of OptiMSM you are trying to dissolve, MSM will dissolve in water to a concentration of about 15-17% by weight at room temperature.

The recommended dose of OptiMSM, as suggested by studies, varies depending on the intended use. For skin health, particularly in reducing visible signs of aging, a daily intake of 1 gram of OptiMSM has been shown to be effective. This dosage led to improvements in skin firmness, elasticity, hydration, and a reduction in wrinkles and skin roughness. It’s important to note that these benefits were observed even at this relatively low dose.

For more specific or detailed dosing recommendations, especially tailored to individual health goals or conditions, it would be best to consult a healthcare provider. Keep in mind that dietary supplements should be used as part of a healthy lifestyle and not as a substitute for a varied diet.

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