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See clearly, stay sharp —Xanthosight® for optimal vision & cognitive function

XanthoSight® is a dietary supplement specifically designed to support your vision, brain function, and skin health.
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XanthoSight® is a clinically proven formula of lutein, zeaxanthin, and meso-zeaxanthin, all xanthophylls extracted from marigold petals.
Our bodies naturally produce some macular pigment, but research suggests it may not be enough for optimal eye health. This pigment, rich in carotenoids like lutein, zeaxanthin, and meso-zeaxanthin, acts as a shield, filtering harmful blue light and protecting our vision. However, studies indicate that a significant portion of the population may have deficiencies in these crucial nutrients.
While lutein and zeaxanthin offer individual benefits, XanthoSight® – a clinically proven blend – may provide a more comprehensive approach. Sourced from Mexican marigold petals, this unique formula delivers a potent combination of lutein, zeaxanthin, and the hard-to-find meso-zeaxanthin in a specifically balanced ratio. This optimized blend may be more effective in supporting macular pigment density and overall eye health compared to individual supplements.
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Carefully harvested from the sun-kissed fields of Mexico, our marigold petals are the source of XanthoSight's potent blend of Lutein, Zeaxanthin and Meso-Zeaxanthin.

Focusing on clarity —
how XanthoSight® supports optimal vision

XanthoSight is clinically proven to increase macular pigment, and improve visual performance including: contrast sensitivity, visual acuity, processing speed, cognitive function, blue light defense, glare recovery and overall wellness throughout the lifespan.

Supports healthy macular function.

Important for central vision.

Helps protect against oxidative stress in the eyes.

Damage caused by free radicals.

May offer protection against harmful blue light.

Emitted from digital screens and sunlight.

May reduce the risk of low macular pigment associated with age

A leading cause of vision loss.

May improve visual acuity and contrast sensitivity.

Sharpness and ability to distinguish details.

May contribute to healthy blood flow to the eyes.

Important for delivering nutrients.

Key Features of XanthoSight® for vision

Clinically Proven Formula

Scientific research backs XanthoSight® for enhancing macular pigment density and visual performance.

Balanced Blend of Xanthophylls

The specific ratio of lutein, zeaxanthin, and meso-zeaxanthin in XanthoSight® is formulated to optimize benefits for vision health.

Natural Source

The xanthophylls in XanthoSight® are sourced from Mexican marigold petals, providing a natural approach to vision support.

Easy-to-Take Format

XanthoSight® may come in capsules or other convenient forms for daily supplementation.

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Contact us today to learn more about how Xanthosight can help you to deliver exceptional products to your customers.
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See clearly, think sharper, heighten brain function: how xanthophylls support your wellbeing

The benefits of XanthoSight® extend far beyond supporting healthy vision. This innovative formula unlocks the potential of xanthophylls for your overall well-being, impacting your cognitive function and skin health.
Xanthophylls are crucial for protecting and supporting three vital organs:

Vision

Certain xanthophylls accumulate in the macula, the central area of your retina responsible for sharp central vision. XanthoSight® helps build macular pigment density, acting as a natural filter for harmful blue light and potentially reducing the risk of age-related vision changes.

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Cognitive Health

Research suggests that xanthophylls may play a significant role in cognitive function. By promoting healthy brain function, XanthoSight® may contribute to improved memory, focus, and overall cognitive performance, potentially protecting against cognitive decline.

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Skin

Xanthophylls possess antioxidant properties that may help shield your skin from sun damage. By neutralizing free radicals generated by UV exposure, XanthoSight® can potentially promote overall skin health and reduce visible signs of aging.

The Science Behind Xanthosight®

XanthoSight® is backed by rigorous scientific research and clinical studies, ensuring its efficacy in promoting eye health and visual performance.

Clinically Proven Ratio

XanthoSight® provides Lutein, Meso-Zeaxanthin, and Zeaxanthin in a clinically proven ratio for optimal vision, brain function, and overall wellness.

Free-Form Carotenoids

The carotenoids in XanthoSight® are extracted from marigold petals in their naturally occurring, bioavailable "free-form" state, enhancing absorption and effectiveness.

Macular Pigment Density

Clinical studies have shown that XanthoSight® significantly increases macular pigment density, which is directly related to visual performance and eye health

Frequently asked questions

Contact us for any additional questions, we’re happy to help.
The evidence that the carotenoids are beneficial for the brain is seen (mainly) from the following evidence/studies:
  • We know that the amount of carotenoid in the retina (which we can measure) is related to brain concentrations if these nutrients;[1]
  • Individuals with high amounts of carotenoids in their blood and retina have enhanced cognitive function compared to individuals with low amounts of carotenoids in their retina;[2, 3]
  • Supplementation with the 3 macular carotenoids (Xanthosight) significantly enhances memory in the healthy population; [4]
  • Patients with Alzheimer’s disease have significantly lower amounts of macular pigment compared to age-matched controls;[5]
  • Supplementation with the 3 macular carotenoids (Xanthosight) significantly enhances macular pigment in patients with Alzheimer’s disease;[6]
  • Supplementation with the 3 macular carotenoids (Xanthosight) plus omega-3 fatty acids significantly enhances macular pigment and improves quality of life in patients with Alzheimer’s disease.[7]
You will see from these studies which represent the main work in brain and carotenoids, that the formulations tested in the clinical studies include the 3 carotenoids and not just lutein.
  1. Johnson, E.J., et al., Relationship between serum and brain carotenoids,-tocopherol, and retinol concentrations and cognitive performance in the oldest old from the Georgia Centenarian Study. Journal of aging research, 2013. 2013.
  2. Feeney, J., et al., Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults. Neurobiol. Aging, 2013. 34(11): p. 2449-2456.
  3. Feeney, J., et al., Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on Aging. J Gerontol A Biol Sci Med Sci, 2017. 72(10): p. 1431-1436.
  4. Power, R., et al., Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Alzheimers Dis, 2018. 61(3): p. 947-961.
  5. Nolan, J., et al., Macular Pigment, Visual Function, and Macular Disease among Subjects with Alzheimer’s Disease: An Exploratory Study. Vol. 42. 2014a.
  6. Nolan, J.M., et al., The impact of supplemental macular carotenoids in Alzheimer’s disease: a randomized clinical trial. J Alzheimers Dis, 2015. 44(4): p. 1157-69.
  7. Nolan, J.M., et al., Nutritional Intervention to Prevent Alzheimer’s Disease: Potential Benefits of Xanthophyll Carotenoids and Omega-3 Fatty Acids Combined. J Alzheimers Dis, 2018. 64(2): p. 367-378.
Meso-zeaxanthin is the central carotenoid and dominant at the macula. It is also the carotenoid with strongest antioxidant potential. We know that individuals at risk of AMD have a deficiency in their central macular pigment[1] and that the only way to rebuild the pigment is to supplement with a formulation containing meso-zeaxanthin.[2] The only way to be sure that the individual will respond is to supplement with meso-zeaxanthin. Some individuals are not able to convert lutein to meso-zeaxanthin.
  1. Kirby, M.L., et al., A Central Dip in the Macular Pigment Spatial Profile is Associated with Age and Smoking. Invest Ophthalmol. Vis. Sci, 2010
  2. Nolan, J.M., et al., Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment. Exp Eye Res, 2012. 101: p. 9-15.
Meso-zeaxanthin was first identified in 1997.[1] In 2010, the first human studies were published in Waterford Ireland [2] and since then there have been over 15 head-to-head clinical studies demonstrating the importance and superiority of meso-zeaxanthin in the formulation, including major studies funded by the European Research Council.[3, 4]
  1. Bone, R.A., et al., Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res, 1997. 64(2): p. 211-8.
  2. Connolly, E.E., et al., Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study. Curr Eye Res, 2010. 35(4): p. 335-51.
  3. Nolan, J.M., et al., Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1. Invest Ophthalmol Vis Sci, 2016. 57(7): p. 3429-39.
  4. Akuffo, K.O., et al., The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial. Invest Ophthalmol Vis Sci, 2017. 58(12): p. 5347-5360.
It is true that all lutein supplements will contain small (trace) amounts of meso-zeaxanthin as they come from the same source (the Marigold Flower). However, the amounts found in these supplements are not sufficient to optimize circulating levels in blood or  tissue levels.
The free from carotenoids or xanthophylls are molecules that have been separated from the fatty acids, such as palmitic, myristic, stearic, etc.  Thus, they are in free form and have a smaller molecular weight because they have the esters (fatty acids from the plant) removed. This makes them a more purified compound.
The main differences is in the science!  Xanthosight® research studied healthy and diseased populations with a wide age range.  AREDS studies were performed only on diseased populations with intermediate AMD.  Only Xanthosight, with meso-zeaxanthin shows significant effects for cognition and memory, vision performance, acuity, macular pigment health, glare, and contrast sensitivity.  AREDS studies showed limited effects on AMD starting with intermediate progression.
Below is just one animal study that suggests that both Lutein and Zeaxanthin cross the BBB but no mention of MZ.  Yes, MZ does cross the BBB. Importantly, all the clinical studies that have used this formulation have proven efficacy and functional benefits (see all the clinical trials on Nolan’s website). We’d be happy to schedule a call to discuss the details of the study below.  Also, we see from the studies conducted by Nolan’s team that meso-zeaxanthin is taken up by all major organs following supplementation with this carotenoid. See https://profjohnnolan.com/wp-content/uploads/2018/05/phelan-et-al-2018.pdf  and https://www.ncbi.nlm.nih.gov/pubmed/22780947
Meso-zeaxanthin is produced at an industrial level from the lutein obtained from marigold petals. The process involves saponification at high temperatures and high alkaline conditions, and results in isomerization of lutein to Meso-zeaxanthin.  Does the industrial process yield a natural product?   Yes, the process to concentrate MZ by Industrial Organica is an normal, industry wide process to produce free form carotenioids from marigolds.  The results in a natural compound. Meso-zeaxanthin produced from this extraction process is not synthetic. It is the exact same molecular structure as that found in the retina.
The most efficacious and researched form is in oil and softgel delivery.  We do have stable beadlets and powder available, these should also be handled carefully with limited exposure to light and oxygen. Oil forms are the most stable and have a longer shelf life.  The beadlets, as made by Industrial Orgánica, are also very stable as they have a small surface area.  Powders have a lerge surface area and are much more expoed to air, oxygen and heat.
The quick answer is that, in the absence of supplementing, we are all suboptimal in terms of macular pigment levels. In Nolan’s  work with Xanthosight, all participants in the study demonstrated a meaningful improvement in macular pigment response. We can all do better with safe and targeted supplementation. 12% of the population have central dips in macular pigment and only meso-zeaxanthin will rebuild the pigment for these individuals. Individuals with a family history of AMD, those who smoke cigarettes, those with high BMI have lower amounts of pigment. Diet is also important, given the dietary origin of these carotenoids.

Meso-zeaxanthin is one of the three stereoisomers found in the eye.  With the devolution of our crops, It is not present in plants in significant amounts, but is found in marine species.   For this reason, it is crucial that meso-zeaxanthin be a supplemental product to our food supply for global nutrition. Meso-zeaxanthin, lutein, and 3R, 3´R-zeaxanthin are the main carotenoids in the macula lutea, found in a ratio of 1:1:1, and are collectively referred to as macular pigment (MP). Meso-zeaxanthin is concentrated at the epicenter of the macula, where it accounts for around 50% of MP at this location, with lutein dominating the peripheral macula.

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